Symposium Presentations
نویسندگان
چکیده
Mongolian gerbils are frequently used to study Helicobacter pylori-induced gastritis and its consequences. The presence of some gastric microbiota with a suppressive effect on H. pylori suggests inhibitory gastric bacteria against H. pylori infection. The aim of the present study was to analyze the microbiota in the stomach of Mongolian gerbils with H. pylori infection. In the first infection experiment, according to the frequency of detection of H. pylori urea in fecal samples, the infected gerbils were divided into three groups (frequently detected, moderately detected and infrequently detected). Eubacterium limosum and Lactobacillus spp. were isolated from the frequently detected group and infrequently detected group, respectively. In the second infection experiment, the gastric mucosa samples of H. pylori negative and positive gerbils were orally inoculated to five (group 1) and six (group 2) gerbils, respectively, and these gerbils were challenged with H. pylori infection. Colonization rate (40%) of H. pylori in group 1 was lower than that (67%) in group 2 gerbils. Culture filtrate of gastric mucosa samples of group 1 gerbils inhibited the in vitro growth of H. pylori. Three lactobacilli species of Lactobacillus reuteri, Lactobacillus johnsonii and Lactobacillus murinus were isolated by anerobic culture from the gerbils in groups 1 and 2 and identified by genomic sequencing method. Although these lactobacilli showed no inhibitory effect on adhesion of H. pylori to gastric cells, it was demonstrated that L. murinus exhibited an inhibitory effect on the in vitro growth of H. pylori. Microbial ecology between H. pylori and gastric microbiota in Mongolian gerbil was analyzed by two infection experiments. The results from the experiments, the presence of gastric bacteria with inhibitory effect on H. pylori, were detected. It was suggested that L. murinus isolated from gastric mucosa with inhibitory effect on H. pylori might be a novel probiotics candidate against H. pylori infection. Recent research data obtained by molecular analysis of gastric microbiota will be also presented in the lecture.
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